Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | PDE6D | O43924 | 1/20 | 0.55 |
| ▸ | PDE6A | P16499 | 1/20 | 0.55 |
| ▸ | PDE6G | P18545 | 1/20 | 0.55 |
| ▸ | PDE6B | P35913 | 1/20 | 0.55 |
| ▸ | PDE6C | P51160 | 1/20 | 0.55 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441445 | 0.91 | PDE5A (0.55) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL14378112 | 0.88 | THRB (0.62) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL430575 | 0.87 | THRB (0.61) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL429137 | 0.86 | PDE5A (0.60) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL437074 | 0.84 | KMT2A (0.55) | THRBNPC1RAB9AKMT2AKDM4E | |
| SCHEMBL7069841 | 0.84 | THRB (0.58) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL3059653 | 0.83 | THRB (0.57) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL3062562 | 0.82 | THRB (0.56) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL3054468 | 0.82 | THRB (0.59) | THRBPDE5APDE6DPDE6APDE6G | |
| SCHEMBL3074877 | 0.82 | THRB (0.56) | THRBPDE5APDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |