Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
| ▸ | PDE6A | P16499 | 1/20 | 0.48 |
| ▸ | PDE6G | P18545 | 1/20 | 0.48 |
| ▸ | PDE6B | P35913 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437005 | 0.91 | THRB (0.60) | PDE5ATHRBKDM4ENPC1RAB9A | |
| SCHEMBL651326 | 0.87 | PDE5A (0.56) | PDE5ATHRBKDM4EMAPTKMT2A | |
| SCHEMBL649687 | 0.86 | PDE5A (0.60) | PDE5ATHRBKDM4EMAPTKMT2A | |
| SCHEMBL439008 | 0.84 | NMT2 (0.60) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL438198 | 0.84 | MAPK1 (0.63) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL437947 | 0.83 | KMT2A (0.53) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4352879 | 0.82 | MAPT (0.65) | PDE5ATHRBMAPTSMN1; SMN2KMT2A | |
| SCHEMBL439271 | 0.81 | MAPK1 (0.65) | THRBKDM4ENPC1RAB9AMAPT | |
| SCHEMBL437781 | 0.81 | MAPT (0.61) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL441687 | 0.81 | KMT2A (0.62) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |