Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368132 | 1.00 | CYP3A4 (0.61) | CYP3A4CYP2C9CYP2C19EPAS1RORC | |
| SCHEMBL14547411 | 0.92 | CYP3A4 (0.65) | CYP3A4CYP2C9CYP2C19RORC | |
| SCHEMBL4374824 | 0.92 | CYP3A4 (0.65) | CYP3A4CYP2C9CYP2C19RORC | |
| SCHEMBL4374818 | 0.92 | CYP3A4 (0.65) | CYP3A4CYP2C9CYP2C19RORC | |
| SCHEMBL4378326 | 0.91 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2C19EPAS1 | |
| SCHEMBL4378333 | 0.91 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2C19EPAS1 | |
| SCHEMBL4379876 | 0.90 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2C19EPAS1 | |
| SCHEMBL4379873 | 0.90 | CYP3A4 (0.49) | CYP3A4CYP2C9CYP2C19EPAS1 | |
| SCHEMBL4379310 | 0.90 | CYP3A4 (0.72) | CYP3A4CYP2C9CYP2C19EPAS1 | |
| SCHEMBL13581455 | 0.90 | CYP3A4 (0.72) | CYP3A4CYP2C9CYP2C19EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937651-B1 | NNRT INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | EP | claimed |
| EP-1937651-A1 | NNRT INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039463-A1 | NNRT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-12 | — | — | WO | claimed |
| US-7625897-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1937651-B1 | NNRT INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | EP | disclosed |
| EP-1937651-A1 | NNRT INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039463-A1 | NNRT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-12 | — | — | WO | disclosed |
| US-20070078128-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078128-A1 | Non-nucleoside reverse transcriptase inhibitors | SAMHD1, HPRT1, RTF1 | CYP3A4 350/4885CYP2C9 1239/4885CYP2C19 1386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.