Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1155038 | 0.76 | KCNH2 (0.64) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL5006578 | 0.66 | KDM4E (0.77) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL30306078 | 0.66 | KDM4E (0.77) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL16546848 | 0.66 | KDM4E (0.56) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL16546845 | 0.66 | KDM4E (0.56) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL1154906 | 0.64 | KCNH2 (0.68) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL13923335 | 0.64 | KDM4E (0.80) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9728544 | 0.64 | ADRB2 (0.44) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL22381272 | 0.64 | KDM4E (0.54) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10812406 | 0.63 | KDM4E (0.61) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064792-A1 | QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES | CUMBRE PHARMACEUTICALS INC. (US) | 2009-05-22 | — | — | WO | disclosed |