Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | GSK3A | P49840 | 2/20 | 0.30 |
| ▸ | GSK3B | P49841 | 2/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369192 | 0.88 | NR3C1 (0.41) | NR3C1PGRARTRPV1 | |
| SCHEMBL3540967 | 0.73 | NR3C1 (0.44) | NR3C1PGRARTRPV1 | |
| SCHEMBL4645789 | 0.72 | PDK2 (0.38) | NR3C1PGRARCYP2D6SLC6A2 | |
| SCHEMBL4645791 | 0.72 | PDK2 (0.38) | NR3C1PGRARCYP2D6SLC6A2 | |
| SCHEMBL3533194 | 0.71 | NR3C1 (0.49) | NR3C1PGRARHCRTR1HCRTR2 | |
| SCHEMBL3532208 | 0.71 | NR3C1 (0.73) | NR3C1PGRARTRPV1MAPT | |
| SCHEMBL3531100 | 0.70 | NR3C1 (0.56) | NR3C1PGRARTRPV1GSK3A | |
| SCHEMBL3534651 | 0.70 | NR3C1 (0.45) | NR3C1PGRARPDK2 | |
| SCHEMBL3534867 | 0.69 | NR3C1 (0.60) | NR3C1PGRARHCRTR1HCRTR2 | |
| SCHEMBL3534862 | 0.69 | NR3C1 (0.60) | NR3C1PGRARHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638515-B2 | improved selectivity and pharmacokinetic properties; 6-Fluoro-1-[(1 H-indazol-4-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene-2,5-diol; cyclization of imines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-29 | — | — | US | claimed |