Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371017 | 0.88 | NR3C1 (0.38) | NR3C1PGRARTRPV1 | |
| SCHEMBL3537525 | 0.76 | NR3C1 (0.55) | NR3C1PGRAR | |
| SCHEMBL3539690 | 0.76 | NR3C1 (0.42) | NR3C1PGRAR | |
| SCHEMBL4368727 | 0.74 | NR3C1 (0.49) | NR3C1PGRARTRPV1 | |
| SCHEMBL4358611 | 0.74 | NR3C1 (0.51) | NR3C1PGRARTRPV1 | |
| SCHEMBL4355542 | 0.73 | NR3C1 (0.51) | NR3C1PGRARTRPV1 | |
| SCHEMBL4369052 | 0.73 | NR3C1 (0.52) | NR3C1PGRARTRPV1 | |
| SCHEMBL4361219 | 0.73 | NR3C1 (0.48) | NR3C1PGRARTRPV1 | |
| SCHEMBL4360032 | 0.73 | NR3C1 (0.50) | NR3C1PGRARTRPV1 | |
| SCHEMBL3532110 | 0.71 | NR3C1 (0.48) | NR3C1PGRARTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638515-B2 | improved selectivity and pharmacokinetic properties; 6-Fluoro-1-[(1 H-indazol-4-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene-2,5-diol; cyclization of imines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-29 | — | — | US | claimed |