Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.54 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372051 | 1.00 | CNR1 (0.54) | CNR1CNR2TRPV1CRHR1TSHR | |
| SCHEMBL4380007 | 0.84 | CNR1 (0.60) | CNR1CNR2TRPV1CRHR1TSHR | |
| SCHEMBL4371549 | 0.84 | CNR1 (0.57) | CNR1CNR2TRPV1CRHR1CRHR2 | |
| SCHEMBL4373566 | 0.82 | CNR1 (0.58) | CNR1CNR2TRPV1CRHR1TSHR | |
| SCHEMBL4372633 | 0.79 | CNR1 (0.46) | CNR1CRHR1TSHR | |
| SCHEMBL4367898 | 0.77 | CNR1 (0.46) | CNR1CNR2CRHR1MDM2 | |
| SCHEMBL4367893 | 0.77 | CNR1 (0.46) | CNR1CNR2CRHR1MDM2 | |
| SCHEMBL4367901 | 0.77 | CNR1 (0.46) | CNR1CNR2CRHR1MDM2 | |
| SCHEMBL4367963 | 0.76 | CNR1 (0.47) | CNR1CNR2TRPV1CRHR1TSHR | |
| SCHEMBL4420518 | 0.76 | CNR1 (0.63) | CNR1CNR2CRHR1TSHRCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |