⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1271231 | 0.77 | — | — | |
| SCHEMBL10853339 | 0.70 | — | — | |
| SCHEMBL30629321 | 0.68 | — | — | |
| SCHEMBL5024965 | 0.64 | — | — | |
| SCHEMBL7147350 | 0.64 | — | — | |
| SCHEMBL9162828 | 0.57 | — | — | |
| SCHEMBL7174682 | 0.57 | — | — | |
| SCHEMBL10741690 | 0.55 | — | — | |
| SCHEMBL18525220 | 0.51 | — | — | |
| SCHEMBL8865294 | 0.48 | HSP90AA1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114014815-B | Preparation method of environment-friendly 4-amino-2, 6-dimethoxy pyrimidine | 浙江科技学院 | 2023-05-30 | — | — | CN | disclosed |
| CN-110981816-B | Synthesis method of 4-amino-2, 6-dimethoxypyrimidine | 天和药业股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-114014815-A | Preparation method of environment-friendly 4-amino-2, 6-dimethoxypyrimidine | 浙江科技学院 | 2022-02-08 | — | — | CN | disclosed |
| CN-110981816-A | Synthesis method of 4-amino-2, 6-dimethoxypyrimidine | 扬州天和药业有限公司 | 2020-04-10 | — | — | CN | disclosed |
| US-20090215777-A1 | Pyrimidine Derivatives As HSP90 Inhibitors | ASTEX THERAPEUTICS LTD. (GB) | 2009-08-27 | — | — | US | disclosed |