Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.32 |
| ▸ | SGMS1 | Q86VZ5 | 2/20 | 0.32 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370115 | 0.77 | KCNH2 (0.41) | KCNH2CYP3A4KDM4E | |
| SCHEMBL1155038 | 0.76 | KCNH2 (0.64) | KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL4370489 | 0.70 | KDM4E (0.36) | KCNH2GPR119KDM4E | |
| SCHEMBL1155088 | 0.66 | JAK2 (0.51) | GPR119USP30KDM4EPKMLIMK2 | |
| SCHEMBL6527477 | 0.64 | KCNH2 (0.72) | KCNH2CYP3A4KDM4E | |
| SCHEMBL1154906 | 0.63 | KCNH2 (0.68) | KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL1154988 | 0.61 | GPR119 (0.40) | GPR119KDM4EPKM | |
| SCHEMBL26101487 | 0.60 | GPR119 (0.50) | GPR119JAK2JAK1 | |
| SCHEMBL26101492 | 0.60 | GPR119 (0.50) | GPR119JAK2JAK1 | |
| SCHEMBL1088765 | 0.60 | KDM4E (0.42) | MEN1KMT2AGPR119KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064792-A1 | QUINOLONE CARBOXYLIC ACID-SUBSTITUTED RIFAMYCIN DERIVATIVES | CUMBRE PHARMACEUTICALS INC. (US) | 2009-05-22 | — | — | WO | disclosed |