SCHEMBL4371877

SCHEMBL4371877

Cc1ccc(Oc2ccc(F)cc2)cc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HTR2A P28223 5/20 0.44
SLC6A4 P31645 5/20 0.44
KCNH2 Q12809 5/20 0.44
SOS1 Q07889 1/20 0.42
PPARA Q07869 5/20 0.42
SCN9A Q15858 1/20 0.42
PPARD Q03181 3/20 0.41
PPARG P37231 3/20 0.41
CYP3A4 P08684 2/20 0.41
AR P10275 1/20 0.41
CHEK2 O96017 1/20 0.40
SLC22A12 Q96S37 1/20 0.40
PDE2A O00408 1/20 0.40
PDE10A Q9Y233 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
HSP90AA1 P07900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14396803 0.88 HTR2A (0.51) SMN1; SMN2HTR2ASLC6A4KCNH2SOS1
SCHEMBL14396817 0.85 SOS1 (0.54) NPC1RAB9ASMN1; SMN2HTR2ASLC6A4
SCHEMBL257839 0.85 HTR2A (0.44) SMN1; SMN2HTR2ASLC6A4KCNH2SOS1
SCHEMBL675954 0.84 HTR2A (0.54) SMN1; SMN2HTR2ASLC6A4KCNH2SOS1
SCHEMBL8736417 0.84 TEAD4 (0.48) SMN1; SMN2HTR2ASLC6A4KCNH2CYP3A4
SCHEMBL15869701 0.82 DRD2 (0.54) SMN1; SMN2HTR2ASLC6A4KCNH2CYP3A4
SCHEMBL19175514 0.82 HTR2A (0.53) SMN1; SMN2HTR2ASLC6A4KCNH2SOS1
SCHEMBL14649910 0.82 HSP90AA1 (0.57) HTR2ASLC6A4KCNH2CYP3A4HSP90AA1
SCHEMBL12260919 0.81 HTR2A (0.44) SMN1; SMN2HTR2ASLC6A4KCNH2SOS1
SCHEMBL3235096 0.79 HTR2A (0.47) SMN1; SMN2HTR2ASLC6A4KCNH2SOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019173507-A1 ANTIBACTERIAL AGENTS : ARYLALKYLCARBOXAMIDO PHLOROGLUCINOLS RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2019-09-12 WO disclosed
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed
WO-2009117421-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2009-09-24 WO disclosed