Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373764 | 0.89 | SLC6A2 (0.42) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 | |
| SCHEMBL4372060 | 0.80 | TRPA1 (0.44) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 | |
| SCHEMBL4374260 | 0.80 | SLC6A2 (0.44) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 | |
| SCHEMBL5169212 | 0.77 | OPRD1 (0.41) | HTR2AHTR2CHTR2BSLC6A4SLC6A2 | |
| SCHEMBL5169204 | 0.77 | OPRD1 (0.41) | HTR2AHTR2CHTR2BSLC6A4SLC6A2 | |
| SCHEMBL5962208 | 0.77 | SLC6A2 (0.35) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 | |
| SCHEMBL27606625 | 0.77 | SLC6A2 (0.47) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 | |
| SCHEMBL5962207 | 0.77 | SLC6A2 (0.35) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 | |
| SCHEMBL4372736 | 0.77 | SLC6A2 (0.39) | HTR2BSLC6A4SLC6A2OPRD1OPRM1 | |
| SCHEMBL4371775 | 0.76 | SLC6A4 (0.47) | SLC6A4SLC6A2OPRD1OPRM1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322592-B2 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-06-17 | — | — | EP | claimed |
| US-7022739-B2 | Substituted 1-aminobutan-3-ol compounds | GRUENENTHAL GMBH (DE) | 2006-04-04 | — | — | US | claimed |
| EP-1322592-B1 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-07-28 | — | — | EP | claimed |
| US-20030216393-A1 | Substituted 1-aminobutan-3-ol compounds | GRUENENTHAL GMBH (DE) | 2003-11-20 | — | — | US | claimed |
| EP-1322592-A1 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | Grünenthal GmbH (DE) | 2003-07-02 | — | — | EP | claimed |
| WO-2002028817-A1 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-11 | — | — | WO | claimed |
| EP-1322592-B2 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-06-17 | — | — | EP | disclosed |
| US-7022739-B2 | Substituted 1-aminobutan-3-ol compounds | GRUENENTHAL GMBH (DE) | 2006-04-04 | — | — | US | disclosed |
| EP-1322592-B1 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-07-28 | — | — | EP | disclosed |
| US-20030216393-A1 | Substituted 1-aminobutan-3-ol compounds | GRUENENTHAL GMBH (DE) | 2003-11-20 | — | — | US | disclosed |
| EP-1322592-A1 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | Grünenthal GmbH (DE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002028817-A1 | SUBSTITUTED 1-AMINOBUTAN-3-OL DERIVATIVES | Grünenthal GmbH (DE) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216393-A1 | Substituted 1-aminobutan-3-ol compounds | CYP3A43, UGT1A3, UGT2B7 | HTR2A 499/4885HTR2C 706/4885HTR2B 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.