Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.64 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.64 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.47 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884027 | 0.87 | ITGB3 (0.76) | ITGAVITGB3ITGB5ITGB1 | |
| SCHEMBL4370191 | 0.84 | ITGB3 (0.76) | ITGAVITGB3ITGB5ITGA2B | |
| SCHEMBL4370498 | 0.84 | ITGB3 (0.76) | ITGAVITGB3ITGB5ITGA2B | |
| SCHEMBL3885042 | 0.84 | ITGB3 (0.66) | ITGAVITGB3ITGB5ITGB1 | |
| SCHEMBL7936710 | 0.84 | ITGAV (0.73) | ITGAVITGB3ITGB5ITGB6ITGB8 | |
| SCHEMBL4381234 | 0.84 | ITGAV (0.73) | ITGAVITGB3ITGB5ITGB6ITGB8 | |
| SCHEMBL4371975 | 0.80 | ITGB3 (0.41) | ITGAVITGB3 | |
| SCHEMBL7945748 | 0.80 | ITGAV (0.77) | ITGAVITGB3ITGB5ITGB6ITGB8 | |
| SCHEMBL7945753 | 0.80 | ITGAV (0.77) | ITGAVITGB3ITGB5ITGB6ITGB8 | |
| SCHEMBL3889356 | 0.80 | ITGAV (0.72) | ITGAVITGB3ITGB5ITGB6ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |