Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | CRHBP | P24387 | 2/20 | 0.76 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.61 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3151838 | 1.00 | MAPT (0.76) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL27291251 | 1.00 | MAPT (0.76) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL21620312 | 0.87 | MAPT (0.79) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL3156221 | 0.87 | MAPT (0.74) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL1821157 | 0.87 | MAPT (0.74) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL23367859 | 0.85 | RAB9A (0.64) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL21620296 | 0.85 | RAB9A (0.64) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL10050572 | 0.85 | MAPT (0.71) | MAPTCRHBPCRHR2GAASMN1; SMN2 | |
| SCHEMBL17365594 | 0.84 | POLB (0.66) | MAPTGAASMN1; SMN2LMNA | |
| SCHEMBL7748974 | 0.84 | POLB (0.66) | MAPTGAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255726-B1 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-11-11 | — | — | EP | disclosed |