Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Domperidone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 6/20 | 1.00 |
| ▸ | DRD3 | P35462 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | HRH1 | P35367 | 3/20 | 1.00 |
| ▸ | HTR2B | P41595 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Domperidone SCHEMBL29373565 | 1.00 | OPRM1 (1.00) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| SCHEMBL11509148 | 1.00 | OPRM1 (1.00) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Domperidone SCHEMBL27988838 | 0.99 | OPRM1 (0.98) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Domperidone SCHEMBL29177488 | 0.99 | OPRM1 (0.98) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Domperidone SCHEMBL5569643 | 0.99 | OPRM1 (0.98) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Domperidone SCHEMBL11506647 | 0.98 | OPRM1 (0.96) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Water SCHEMBL11508184 | 0.97 | DRD2 (0.94) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Water SCHEMBL11508185 | 0.97 | DRD2 (0.94) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| SCHEMBL11507685 | 0.95 | DRD2 (0.90) | OPRM1DRD2DRD3SLC6A4HTR1A | |
| Domperidone SCHEMBL11507534 | 0.94 | DRD2 (0.89) | OPRM1DRD2DRD3SLC6A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 20286 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122031470-A | Application of domperidone in preparing pharmaceutical preparation for treating inflammatory dermatosis | 中国药科大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122004156-A | Method for cultivating GCRV-resistant grass carp strain based on artificial gynogenesis | 湖南师范大学 | 2026-05-12 | — | — | CN | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| WO-2026090593-A2 | RNA BIOMARKERS FOR USE IN BARRETT'S ESOPHAGUS | CITY OF HOPE (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260092141-A1 | SERIES OF POLYMERS HAVING PROPERTIES OF ACID-SENSITIVE DEGRADATION AND TEMPERATURE SENSITIVITY AND DRUG LOADING COMPOSITION THEREOF | NANJING FANTAI CHEMICAL PHARMACEUTICAL RESEARCH INSTITUTE (CN) | 2026-04-02 | — | — | US | claimed |
| US-20260083717-A1 | FORMULATIONS CONTAINING DEUTERATED DOMPERIDONE | CINDOME PHARMA INC (US) | 2026-03-26 | — | — | US | claimed |
| US-12582601-B2 | Orodispersible powder composition | BIOPHARMA SYNERGIES, S.L. (ES) | 2026-03-24 | — | — | US | claimed |
| US-20260069593-A1 | METHODS FOR TREATING CANCER | AMGEN INC (US) | 2026-03-12 | — | — | US | claimed |
| US-12529704-B2 | Methods for objective assessment of stress, early detection of risk for stress disorders, matching individuals with treatments, monitoring response to treatment, and new methods of use for drugs | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2026-01-20 | — | — | US | claimed |
| EP-0487674-A1 | INJECTABLE SLOW-RELEASE GALENICAL. | APLICACIONES FARMACEUTICAS (MX) | 1992-06-03 | — | — | EP | claimed |
| WO-1992000735-A1 | ROPINIROLE AND DOMPERIDONE FOR USE IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF PARKINSON'S DISEASE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-01-23 | — | — | WO | claimed |
| CN-1057960-A | DELAY GALENIC PARENTERAL FORM FOR INJECTION | APLICACIONES FARMACEUTICAS (MX) | 1992-01-22 | — | — | CN | claimed |
| WO-1991019485-A1 | INJECTABLE SLOW-RELEASE GALENICAL | APLICACIONES FARMACEUTICAS, S.A. DE C.V. (MX) | 1991-12-26 | — | — | WO | claimed |
| EP-0454773-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | Bundgaard, Hans (DK) | 1991-11-06 | — | — | EP | claimed |
| WO-1990008128-A1 | NOVEL PRODRUG DERIVATIVES OF BIOLOGICALLY ACTIVE AGENTS CONTAINING HYDROXYL GROUPS OR NH-ACIDIC GROUPS | BUNDGAARD HANS (DK) | 1990-07-26 | — | — | WO | claimed |
| WO-1989004179-A1 | PHARMACEUTICAL FORMULATIONS FOR TRANSDERMAL ADMINISTRATION | ALSO LABORATORI S.A.S. (IT) | 1989-05-18 | — | — | WO | claimed |
| US-4772616-A | DOMPERIDONE | THE TEXAS A & M UNIVERSITY SYSTEM (US) | 1988-09-20 | — | — | US | claimed |
| EP-0140789-A2 | Use of peripherally selective dopamine antagonists for the preparation of a medicament for the topical treatment of ocular hypertension | MERCK & CO. INC. (US) | 1985-05-08 | — | — | EP | claimed |
| US-4066772-A | ANTIEMETICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-01-03 | — | — | US | claimed |