Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.43 |
| ▸ | F10 | P00742 | 6/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.43 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PLG | P00747 | 3/20 | 0.38 |
| ▸ | PLAU | P00749 | 3/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 3/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372985 | 1.00 | ST14 (0.43) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1798732 | 0.86 | ADAMTS7 (0.44) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1798731 | 0.86 | ADAMTS7 (0.44) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1801383 | 0.75 | ADAMTS7 (0.50) | ADAMTS7ADAMTS5USP30PLAUMMP7 | |
| SCHEMBL1801386 | 0.75 | ADAMTS7 (0.50) | ADAMTS7ADAMTS5USP30PLAUMMP7 | |
| SCHEMBL1798952 | 0.73 | ADAMTS7 (0.45) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1798953 | 0.73 | ADAMTS7 (0.45) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1798439 | 0.72 | ADAMTS7 (0.46) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1798436 | 0.72 | ADAMTS7 (0.46) | ST14F10TMPRSS6ADAMTS7ADAMTS5 | |
| SCHEMBL1798738 | 0.72 | MMP13 (0.58) | ADAMTS7ADAMTS5MMP7MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |