Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 11/20 | 0.48 |
| ▸ | BCR | P11274 | 9/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948017 | 0.86 | ABL1 (0.56) | CAMKK2ABL1BCRPDGFRAPDGFRB | |
| SCHEMBL22169828 | 0.83 | CAMKK2 (0.59) | CAMKK2AKR1C3ABL1BCRPDGFRA | |
| SCHEMBL22169873 | 0.82 | CAMKK2 (0.74) | CAMKK2ABL1BCRPDGFRAPDGFRB | |
| SCHEMBL22169842 | 0.81 | CAMKK2 (0.63) | CAMKK2ABL1BCRPDGFRAPDGFRB | |
| SCHEMBL29707254 | 0.81 | ABL1 (0.71) | CAMKK2ABL1BCRPDGFRAPDGFRB | |
| SCHEMBL533540 | 0.81 | ABL1 (0.71) | CAMKK2ABL1BCRPDGFRAPDGFRB | |
| SCHEMBL3949460 | 0.81 | CAMKK2 (0.53) | CAMKK2AKR1C3ABL1BCRPDGFRA | |
| SCHEMBL4714996 | 0.80 | CAMKK2 (0.51) | CAMKK2AKR1C3ABL1BCRPDGFRA | |
| SCHEMBL4373857 | 0.80 | KDM4C (0.54) | CAMKK2AKR1C3ABL1BCRPDGFRA | |
| SCHEMBL22169872 | 0.80 | CAMKK2 (0.64) | CAMKK2ABL1BCRPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109991-A2 | NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) | 2009-09-11 | — | — | WO | claimed |