Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653319 | 0.84 | HTR2A (0.44) | POLBMAPTL3MBTL1HTR2AHTR2C | |
| SCHEMBL16431851 | 0.77 | HSD17B10 (0.48) | LMNAALDH1A1HSD17B10KMT2APOLB | |
| SCHEMBL31714447 | 0.74 | ALDH1A1 (0.46) | LMNAALDH1A1HSD17B10KMT2APOLB | |
| SCHEMBL1579468 | 0.73 | KDM4E (0.42) | ALDH1A1KDM4EMAPTMAPK1TSHR | |
| SCHEMBL14116545 | 0.73 | MAPT (0.39) | LMNAALDH1A1HSD17B10KMT2APOLB | |
| SCHEMBL4772225 | 0.72 | TAAR1 (0.47) | ALDH1A1HSD17B10KMT2AKDM4EMEN1 | |
| SCHEMBL20819545 | 0.72 | LMNA (0.49) | LMNAALDH1A1HSD17B10KMT2AKDM4E | |
| SCHEMBL7893305 | 0.71 | ALDH1A1 (0.43) | LMNAALDH1A1HSD17B10KMT2APOLB | |
| SCHEMBL21598387 | 0.71 | TSHR (0.45) | LMNAALDH1A1KMT2AHPGDTSHR | |
| SCHEMBL10967724 | 0.71 | LMNA (0.57) | LMNAALDH1A1HSD17B10KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118072-A1 | 3 - CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | AstraZeneca AB (SE) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008090353-A1 | 3 - CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER | ASTRAZENECA AB (SE) | 2008-07-31 | — | — | WO | disclosed |