Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373096 | 0.86 | NAMPT (0.48) | LMNAMAPK1KMT2AALDH1A1HTT | |
| SCHEMBL15673962 | 0.80 | HDAC1 (0.46) | KMT2AMEN1 | |
| SCHEMBL2841862 | 0.78 | ITGB3 (0.50) | LMNAMAPK1KMT2ARAB9ANPC1 | |
| SCHEMBL2837180 | 0.78 | NPC1 (0.47) | LMNAMAPK1KMT2ARAB9ANPC1 | |
| SCHEMBL2836439 | 0.77 | ITGB3 (0.45) | LMNAMAPK1KMT2ARAB9ANPC1 | |
| SCHEMBL4059253 | 0.77 | NAMPT (0.61) | KMT2ARAB9ANPC1HTTPOLB | |
| SCHEMBL2838511 | 0.77 | ITGB3 (0.43) | LMNAMAPK1KMT2ARAB9ANPC1 | |
| SCHEMBL2842651 | 0.76 | MAPK1 (0.48) | LMNAMAPK1KMT2ARAB9ANPC1 | |
| SCHEMBL2833692 | 0.75 | ITGB3 (0.52) | LMNAMAPK1KMT2ARAB9ANPC1 | |
| SCHEMBL2833089 | 0.74 | ITGB3 (0.48) | LMNAMAPK1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A9 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |