Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 3/20 | 0.54 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CCNH | P51946 | 1/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770646 | 0.89 | DYRK3 (0.69) | DYRK3CISD1CDK1PRKCDCCNB1 | |
| SCHEMBL4377398 | 0.84 | HPGD (0.61) | DYRK3CISD1CDK1PRKCDCCNB1 | |
| SCHEMBL10093419 | 0.81 | DYRK3 (0.80) | DYRK3CISD1CDK1PRKCDCCNB1 | |
| SCHEMBL497545 | 0.81 | DYRK3 (0.80) | DYRK3CISD1CDK1PRKCDCCNB1 | |
| SCHEMBL497544 | 0.81 | DYRK3 (0.80) | DYRK3CISD1CDK1PRKCDCCNB1 | |
| SCHEMBL1249102 | 0.79 | CISD1 (0.71) | CISD1GSK3AGSK3BIGF1RPOLB | |
| SCHEMBL1249100 | 0.79 | CISD1 (0.71) | CISD1GSK3AGSK3BIGF1RPOLB | |
| SCHEMBL4775749 | 0.78 | MEN1 (0.48) | DYRK3CISD1MAPK1GSK3BPTPN11 | |
| SCHEMBL4774341 | 0.78 | MAPT (0.64) | DYRK3CISD1MAPK1PTPN11POLB | |
| SCHEMBL4772304 | 0.77 | DYRK3 (0.68) | DYRK3CISD1GSK3BPTPN11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648452-B1 | 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS | MERCK SERONO SA (CH) | 2009-07-22 | — | — | EP | claimed |