Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 3/20 | 0.68 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772766 | 0.88 | DYRK3 (0.69) | DYRK3PTPN11NPSR1MEN1KMT2A | |
| SCHEMBL4770970 | 0.86 | DYRK3 (0.52) | DYRK3PTPN11NPSR1CISD1MAPT | |
| SCHEMBL4771030 | 0.86 | DYRK3 (0.53) | DYRK3PTPN11NPSR1CISD1MAPT | |
| SCHEMBL4770141 | 0.86 | MEN1 (0.56) | DYRK3PTPN11NPSR1MAPTMEN1 | |
| SCHEMBL4774341 | 0.85 | MAPT (0.64) | DYRK3PTPN11NPSR1CISD1MAPT | |
| SCHEMBL13196736 | 0.81 | DYRK3 (1.00) | DYRK3NPSR1CISD1MAPTMEN1 | |
| SCHEMBL2789883 | 0.81 | DYRK3 (1.00) | DYRK3NPSR1CISD1MAPTMEN1 | |
| SCHEMBL2789882 | 0.81 | DYRK3 (1.00) | DYRK3NPSR1CISD1MAPTMEN1 | |
| SCHEMBL4765545 | 0.80 | DYRK3 (0.57) | DYRK3PTPN11CISD1MAPTMEN1 | |
| SCHEMBL4775749 | 0.79 | MEN1 (0.48) | DYRK3PTPN11NPSR1CISD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |