Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | GRK6 | P43250 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772304 | 0.85 | DYRK3 (0.68) | MAPTNPSR1MEN1KMT2ADYRK3 | |
| SCHEMBL4772766 | 0.84 | DYRK3 (0.69) | NPSR1MEN1KMT2ADYRK3POLB | |
| SCHEMBL4770970 | 0.84 | DYRK3 (0.52) | MAPTNPSR1MEN1KMT2ADYRK3 | |
| SCHEMBL4770141 | 0.84 | MEN1 (0.56) | MAPTNPSR1MEN1KMT2ADYRK3 | |
| SCHEMBL4775749 | 0.84 | MEN1 (0.48) | MAPTNPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL13196738 | 0.83 | DYRK3 (0.74) | MAPTNPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL2788706 | 0.83 | DYRK3 (0.74) | MAPTNPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL2788708 | 0.83 | DYRK3 (0.74) | MAPTNPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL4770725 | 0.82 | DYRK3 (0.51) | MAPTNPSR1MEN1KMT2ADYRK3 | |
| SCHEMBL4771030 | 0.82 | DYRK3 (0.53) | MAPTNPSR1MEN1KMT2ADYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567112-B1 | THIAZOLIDIN-4-ONES FOR INHIBITING hYAK3 PROTEINS | SMITHKLINE BEECHAM CORP (US) | 2008-10-15 | — | — | EP | claimed |