SCHEMBL437463

SCHEMBL437463

COc1ccc(C=O)c(Br)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.66
TRIM24 O15164 1/20 0.63
TYR P14679 1/20 0.63
TRIM33 Q9UPN9 1/20 0.63
ERN1 O75460 3/20 0.58
PRKDC P78527 1/20 0.57
CYP1A2 P05177 5/20 0.50
KDM4E B2RXH2 2/20 0.50
CYP2C19 P33261 2/20 0.50
MAPT P10636 2/20 0.50
CYP1A1 P04798 3/20 0.48
CYP1B1 Q16678 3/20 0.48
CYP2A6 P11509 1/20 0.48
LMNA P02545 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
NPC1 O15118 1/20 0.47
POLB P06746 1/20 0.47
NQO2 P16083 1/20 0.47
RAB9A P51151 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethane SCHEMBL28205235 0.98 ALDH1A1 (0.63) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL1134243 0.88 ALDH1A1 (0.53) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL584683 0.86 ERN1 (0.61) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL24313342 0.85 PRKDC (0.48) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL29558007 0.85 PRKDC (0.48) ALDH1A1TRIM24TYRTRIM33ERN1
Bromide SCHEMBL27667716 0.84 ERN1 (0.59) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL12672585 0.83 ALDH1A1 (0.70) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL29957021 0.83 ALDH1A1 (0.70) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL20535326 0.82 PRKDC (0.47) ALDH1A1TRIM24TYRTRIM33ERN1
SCHEMBL15145284 0.81 LMNA (0.59) ALDH1A1TRIM24TYRTRIM33ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108989-B Resveratrol derivative and preparation method and application thereof 山东大学 2024-04-05 CN claimed
CN-115536509-B Synthesis method of 2-bromo-4-hydroxybenzaldehyde 苏州当量生物医药有限公司 2023-11-07 CN claimed
CN-115536509-A Synthesis method of 2-bromo-4-hydroxybenzaldehyde 苏州金蚕新材料科技有限公司 2022-12-30 CN claimed
CN-115108989-A Resveratrol derivative and preparation method and application thereof 山东大学 2022-09-27 CN claimed
CN-106632070-B A kind of preparation method of PDE4 inhibitor chlorine than Pulan 广州兰晟健智医药科技有限公司 2019-08-06 CN claimed
CN-109608374-A 1,4- dihydroxy-anthracene naphthoquinone derivatives and its preparation method and application 广西大学 2019-04-12 CN claimed
CN-107628925-A A kind of preparation method of 2 phenyl halogenation methylbenzene and its derivative 中国石油化工股份有限公司 2018-01-26 CN claimed
CN-107118087-A A kind of new technique for synthesizing of isovanillin 蚌埠中实化学技术有限公司 2017-09-01 CN claimed
CN-106632070-A Preparation method for chlorbipram PDE4-inhibitor 徐江平 2017-05-10 CN claimed
CN-106243104-A One is to naphthoquinone and pyrimidine heterozygote and synthetic method thereof 新乡医学院 2016-12-21 CN claimed
CN-106188099-A A kind of 1,4 sulfur nitrogen Zhuo derivant and synthetic methods thereof 新乡医学院 2016-12-07 CN claimed
CN-103360315-B Heterocyclic aryloxyacetyl hydrazone derivative and its preparation method and application thereof UNIV SHANDONG 2015-03-04 CN claimed
CN-101921587-B Fluorescent probe having tumor cell proliferation inhibition activity and preparation method thereof UNIV XI AN JIAOTONG 2014-07-02 CN claimed
CN-101240166-B Bromobenzothiazoles luminous agent and preparation method thereof UNIV JIANGNAN 2010-09-29 CN claimed
CN-101240166-A Bromobenzothiazoles luminous agent and preparation method thereof UNIV JIANGNAN (CN) 2008-08-13 CN claimed
EP-4161642-B1 N-PHENYLAMINOCARBONYL PYRIDINO- , PYRIMIDINO AND BENZO-TROPANES AS MODULATORS OF GPR65 PATHIOS THERAPEUTICS LTD (GB) 2026-05-27 EP disclosed
US-12624035-B2 Compounds for targeted protein degradation AMPHISTA THERAPEUTICS LIMITED (GB) 2026-05-12 US disclosed
US-4730068-A SPECIAL EFFECT ON BREAST CANCER ASTA-WERKE AKTIENGESELLSCHAFT (DE) 1988-03-08 US disclosed
CN-86100815-A The preparation method who suppresses (1, the 2-diphenyl ethylene diamine)-platinum (II) complex compound of tumour 1986-11-26 CN disclosed
EP-0193055-A1 Antitumorals(1,2-diphenyl-ethylene diamine)-platinum (II) complexes ASTA Pharma AG (DE) 1986-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12624035-B2 Compounds for targeted protein degradation BRD9, BRD1, BRD3 ALDH1A1 4325/4885TRIM24 472/4885TYR 2321/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.