SCHEMBL4374633

SCHEMBL4374633

Cc1c(OC(=O)NC(C)C(O)C2CC2)cc(-c2cc(C(F)(F)F)ccc2C(F)(F)F)n1C[C@H]1CCCO1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 19/20 0.41
TSHR P16473 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4370570 0.92 CNR2 (0.40) CNR2TSHR
SCHEMBL4375460 0.87 TSHR (0.40) CNR2TSHR
SCHEMBL4373529 0.87 CNR2 (0.39) CNR2TSHR
SCHEMBL4374042 0.86 ALDH1A1 (0.38) CNR2TSHR
SCHEMBL4376045 0.84 TSHR (0.42) CNR2TSHR
SCHEMBL4374742 0.84 TSHR (0.42) CNR2TSHR
SCHEMBL4371354 0.83 CNR2 (0.44) CNR2TSHR
SCHEMBL4382724 0.83 TSHR (0.39) CNR2TSHR
SCHEMBL4380548 0.82 TSHR (0.38) CNR2TSHR
SCHEMBL4369418 0.82 TSHR (0.38) CNR2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1749002-B1 PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY HOFFMANN LA ROCHE (CH) 2009-05-27 EP claimed