SCHEMBL4374700

SCHEMBL4374700

O=C1c2ccc(O)c(O)c2C(=O)N1Cc1ccc(F)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.52
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48
LMNA P02545 2/20 0.45
MEN1 O00255 1/20 0.45
RGS12 O14924 1/20 0.45
USP2 O75604 1/20 0.45
MAPT P10636 1/20 0.45
HTT P42858 1/20 0.45
RECQL P46063 1/20 0.45
KMT2A Q03164 1/20 0.45
HPGD P15428 1/20 0.45
UBE2N P61088 1/20 0.45
ATM Q13315 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
SIRT2 Q8IXJ6 1/20 0.43
SIRT1 Q96EB6 1/20 0.43
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4366780 0.87 CA12 (0.43) CASP3LMNAMEN1RGS12USP2
SCHEMBL13952392 0.85 KMT2A (0.61) CASP3LMNAMEN1RGS12USP2
SCHEMBL4370400 0.85 HDAC4 (0.42) CASP3LMNAMEN1RGS12USP2
SCHEMBL4220045 0.84 MEN1 (0.41) CASP3LMNAMEN1RGS12USP2
SCHEMBL4372311 0.84 PIK3CA (0.48) LMNAMEN1RGS12USP2MAPT
SCHEMBL4369764 0.83 UBE2N (0.51) LMNAMEN1RGS12USP2MAPT
SCHEMBL4225056 0.83 MEN1 (0.40) CASP3LMNAMEN1RGS12USP2
SCHEMBL4377121 0.82 CASP3 (0.60) CASP3CYP1A2CYP2C19LMNAMEN1
SCHEMBL4371112 0.82 APAF1 (0.50) CYP1A2LMNAMEN1RGS12USP2
SCHEMBL4230363 0.81 HDAC4 (0.40) LMNAMEN1RGS12USP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009026248-A2 HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) 2009-02-26 WO claimed
WO-2009026248-A2 HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) 2009-02-26 WO disclosed
WO-2009026248-A2 HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) 2009-02-26 WO disclosed