SCHEMBL437529

SCHEMBL437529

Nc1ccc(C(=O)c2ccc(N)c(Cl)c2)cc1Cl

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.66
POLB P06746 1/20 0.66
SRD5A2 P31213 1/20 0.53
CYP3A4 P08684 4/20 0.50
TSHR P16473 4/20 0.50
RECQL P46063 2/20 0.50
HSD17B10 Q99714 2/20 0.50
THRB P10828 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
CASP1 P29466 1/20 0.50
MAPK1 P28482 2/20 0.48
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47
LMNA P02545 1/20 0.47
HTT P42858 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
VCAM1 P19320 1/20 0.46
LRRK2 Q5S007 1/20 0.45
ESR2 Q92731 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7192071 0.92 ALDH1A1 (0.58) ALDH1A1POLBSRD5A2CYP3A4TSHR
SCHEMBL4608673 0.90 ALDH1A1 (0.71) ALDH1A1POLBSRD5A2ALOX15MAPK1
SCHEMBL7190124 0.87 PBRM1 (0.62) ALDH1A1POLBSRD5A2CYP3A4TSHR
SCHEMBL7194683 0.86 ALDH1A1 (0.53) ALDH1A1POLBSRD5A2CYP3A4TSHR
SCHEMBL99833 0.84 TSHR (0.65) ALDH1A1POLBSRD5A2CYP3A4TSHR
SCHEMBL1469205 0.84 ALDH1A1 (0.54) ALDH1A1POLBSRD5A2CYP3A4TSHR
SCHEMBL879015 0.84 ALDH1A1 (0.54) ALDH1A1POLBCYP3A4TSHRRECQL
SCHEMBL5891955 0.84 ALDH1A1 (0.60) ALDH1A1POLBCYP3A4TSHRHSD17B10
SCHEMBL5794414 0.83 TSHR (0.63) ALDH1A1POLBSRD5A2CYP3A4TSHR
Hydrochloric Acid SCHEMBL11879283 0.83 ALDH1A1 (0.53) ALDH1A1POLBCYP3A4TSHRRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 201 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3405453-B1 A METHOD FOR PREPARING POLY(CARBONATE-ETH ERIMIDE) COMPOUND PTT GLOBAL CHEMICAL PUBLIC CO LTD (TH) 2024-05-29 EP claimed
US-10759904-B2 Method for preparing poly(carbonate-etherimide) compound PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) 2020-09-01 US claimed
US-20190202980-A1 METHOD FOR PREPARING POLY(CARBONATE-ETHERIMIDE) COMPOUND PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED (TH) 2019-07-04 US claimed
EP-3405453-A2 A METHOD FOR PREPARING POLY(CARBONATE-ETH ERIMIDE) COMPOUND PTT Global Chemical Public Company Limited (TH) 2018-11-28 EP claimed
CN-108884032-A The method for preparing poly- (carbonic ester-etherimide) compound PTT全球化学股份有限公司 2018-11-23 CN claimed
US-20070009751-A1 Polyamic acid resin composition modified with laminate nanometer silica sheet and polyimide prepared therefrom CHANG CHUN PLASTICS CO., LTD. (TW) 2007-01-11 US claimed
EP-1021478-B1 PHTHALONITRILE THERMOSET POLYMERS AND COMPOSITES CURED WITH HALOGEN-CONTAINING AROMATIC AMINE CURING AGENTS and process for producing them US GOV SEC NAVY (US) 2005-01-19 EP claimed
US-20040110014-A1 Organic-inorganic hybrid film material and its fabrication CHANG CHUN PLASTICS CO., LTD. (TW) 2004-06-10 US claimed
EP-1021478-A4 PHTHALONITRILE THERMOSET POLYMERS AND COMPOSITES CURED WITH HALOGEN-CONTAINING AROMATIC AMINE CURING AGENTS US NAVY (US) 2000-12-13 EP claimed
EP-1021478-A1 PHTHALONITRILE THERMOSET POLYMERS AND COMPOSITES CURED WITH HALOGEN-CONTAINING AROMATIC AMINE CURING AGENTS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY (US) 2000-07-26 EP claimed
WO-1999018145-A1 PHTHALONITRILE THERMOSET POLYMERS AND COMPOSITES CURED WITH HALOGEN-CONTAINING AROMATIC AMINE CURING AGENTS THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1999-04-15 WO claimed
US-4886873-A ELASTICITY AND HEAT RESISTANCE DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 1989-12-12 US claimed
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof HUNTSMAN ADVANCED MATERIALS AMERICAS LLC 2025-07-22 US disclosed
EP-3405453-B1 A METHOD FOR PREPARING POLY(CARBONATE-ETH ERIMIDE) COMPOUND PTT GLOBAL CHEMICAL PUBLIC CO LTD (TH) 2024-05-29 EP disclosed
US-20230111073-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER AQUAPORIN A/S (DK) 2023-04-13 US disclosed
US-20230087170-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER AQUAPORIN A/S (DK) 2023-03-23 US disclosed
US-4026871-A Chain-extending phenolic end-capped polyimides UNIVERSITY OF NOTRE DAME (US) 1977-05-31 US disclosed
US-3998786-A USEFUL FOR PREPARING COATINGS UNIVERSITY OF NOTRE DAME DU LAC (US) 1976-12-21 US disclosed
US-3996196-A Polyimide-metallo-phthalocyanines and their preparation UNIVERSITY OF NOTRE DAME DU LAC (US) 1976-12-07 US disclosed
US-3987003-A THERMALLY STABLE DIOXO AND DITHIO-BENZISOQUINOLINE COMPOSITIONS AND PROCESS OF SYNTHESIZING SAME THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1976-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12365763-B2 Phthalonitrile resins, methods of making same and compositions thereof PNN, PAH, CUL4B ALDH1A1 2253/4885POLB 3255/4885SRD5A2 4414/4885
US-20230111073-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER CHMP4B, VMA21, VAMP8 ALDH1A1 4599/4885POLB 4372/4885SRD5A2 4390/4885
US-20230087170-A1 METHOD OF PREPARING A THIN FILM COMPOSITE LAYER CHMP4B, VMA21, VAMP8 ALDH1A1 4599/4885POLB 4372/4885SRD5A2 4390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.