Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | LYPLAL1 | Q5VWZ2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692531 | 0.85 | PKM (0.58) | PKMMAPTPKLRKDM4EHDAC3 | |
| SCHEMBL692366 | 0.82 | CYP2A6 (0.47) | KDM4EDYRK1ACA12CA2 | |
| SCHEMBL5984006 | 0.81 | PKM (0.55) | PKMMAPTPKLRKDM4EHDAC3 | |
| SCHEMBL5747283 | 0.76 | PKM (0.49) | PKMMAPTPKLRKDM4EKEAP1 | |
| SCHEMBL2530001 | 0.73 | KAT6A (0.45) | PKMMAPTPKLRPTGS1PTGS2 | |
| SCHEMBL18527086 | 0.71 | DYRK1A (0.39) | PKMMAPTKDM4EHDAC3HDAC4 | |
| SCHEMBL9412823 | 0.70 | PKM (0.46) | PKMMAPTPKLRKDM4EHDAC3 | |
| SCHEMBL8164691 | 0.70 | PKM (0.57) | PKMMAPTPKLRKDM4EHDAC3 | |
| SCHEMBL968326 | 0.70 | PKM (0.57) | PKMMAPTPKLRKDM4EKEAP1 | |
| SCHEMBL2633941 | 0.70 | PKM (0.57) | PKMMAPTPKLRKDM4EHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750696-A4 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1750696-A2 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS, INC. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005110428-A2 | RESISTANCE-REPELLENT RETROVIRAL PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS, INC. (US) | 2005-11-24 | — | — | WO | disclosed |