SCHEMBL5747283

SCHEMBL5747283

O=S(=O)(Cl)c1ccc2c(c1)CCCO2

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 4/20 0.49
MAPT P10636 1/20 0.49
KEAP1 Q14145 2/20 0.48
NFE2L2 Q16236 2/20 0.48
TRIM24 O15164 1/20 0.48
BRD1 O95696 1/20 0.48
BRPF1 P55201 1/20 0.48
CLK1 P49759 1/20 0.44
DYRK1A Q13627 1/20 0.44
DYRK1B Q9Y463 1/20 0.44
PKLR P30613 1/20 0.44
CTNNB1 P35222 4/20 0.43
WNT3A P56704 4/20 0.43
NOTUM Q6P988 1/20 0.43
CHRM5 P08912 2/20 0.41
PRKCI P41743 1/20 0.39
KDM4E B2RXH2 1/20 0.39
BRD4 O60885 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL692531 0.90 PKM (0.58) PKMMAPTKEAP1NFE2L2DYRK1A
SCHEMBL19692944 0.87 USP9X (0.45) PKMMAPTKEAP1NFE2L2TRIM24
SCHEMBL5984006 0.85 PKM (0.55) PKMMAPTKEAP1NFE2L2DYRK1A
SCHEMBL6674134 0.83 CA2 (0.59) PKMMAPTKEAP1NFE2L2TRIM24
SCHEMBL6307961 0.83 KEAP1 (0.51) PKMMAPTKEAP1NFE2L2TRIM24
SCHEMBL12596097 0.83 TRIM24 (0.51) PKMMAPTKEAP1NFE2L2TRIM24
SCHEMBL1020435 0.81 FFAR4 (0.54) PKMMAPTPKLR
SCHEMBL3776295 0.80 KEAP1 (0.54) PKMMAPTKEAP1NFE2L2TRIM24
SCHEMBL706682 0.77 PKM (0.61) PKMMAPTPKLR
SCHEMBL9412823 0.77 PKM (0.46) PKMMAPTKEAP1NFE2L2PKLR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4692094-A1 SULFONAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF Beijing Konruns Pharmaceutical Co., Ltd. (CN) 2026-02-11 EP disclosed
US-20230303552-A1 ARYLSULFONYL DERIVATIVES AND THEIR USE AS MUSCARINIC ACETYLCHOLINE RECEPTOR M5 INHIBITORS VANDERBILT UNIVERSITY 2023-09-28 US disclosed
US-20230303552-A1 ARYLSULFONYL DERIVATIVES AND THEIR USE AS MUSCARINIC ACETYLCHOLINE RECEPTOR M5 INHIBITORS VANDERBILT UNIVERSITY 2023-09-28 US disclosed
WO-2023150525-A1 COMPETITIVE AND NONCOMPETITIVE PIPERIDINE SULFONYL INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 VANDERBILT UNIVERSITY (US) 2023-08-10 WO disclosed
WO-2023150526-A1 COMPETITIVE AND NONCOMPETITIVE OCTAHYDROCYCLOPENTA[C]PYRROLE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 VANDERBILT UNIVERSITY (US) 2023-08-10 WO disclosed
US-20230183237-A1 COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 VANDERBILT UNIVERSITY 2023-06-15 US disclosed
US-20230183237-A1 COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 VANDERBILT UNIVERSITY 2023-06-15 US disclosed
US-20230183237-A1 COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 VANDERBILT UNIVERSITY 2023-06-15 US disclosed
US-11560386-B2 Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2023-01-24 US disclosed
EP-3464292-B1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO ARENA PHARM INC (US) 2022-09-21 EP disclosed
EP-3464292-A1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2019-04-10 EP disclosed
WO-2017214002-A1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2017-12-14 WO disclosed
WO-2017209155-A1 SULFONAMIDE COMPOUND OR SALT THEREOF 大鵬薬品工業株式会社 2017-12-07 WO disclosed
US-20170298016-A1 PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF HITGEN INC. (CN) 2017-10-19 US disclosed
US-8354548-B2 Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase BRISTOL-MYERS SQUIBB COMPANY (US) 2013-01-15 US disclosed
US-8354548-B2 Glycine chroman-6-sulfonamides for use as inhibitors of diacylglycerol lipase BRISTOL-MYERS SQUIBB COMPANY (US) 2013-01-15 US disclosed
US-20110207772-A1 Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase BRISTOL-MYERS SQUIBB COMPANY 2011-08-25 US disclosed
US-20110207772-A1 Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase BRISTOL-MYERS SQUIBB COMPANY 2011-08-25 US disclosed
EP-1735280-A1 ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS Kalypsys, Inc. (US) 2006-12-27 EP disclosed
WO-2005115983-A1 ARYL SULFONAMIDE AND SULFONYL COMPOUNDS AS MODULATORS OF PPAR AND METHODS OF TREATING METABOLIC DISORDERS KALYPSYS, INC. (US) 2005-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170298016-A1 PYRROLIC AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF HDAC1, HDAC3, HDAC11 PKM 866/4885MAPT 3879/4885KEAP1 2431/4885
US-20230183237-A1 COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5 CHRM5, CHRM1, CHRM2 PKM 1092/4885MAPT 2286/4885KEAP1 2451/4885
US-20230303552-A1 ARYLSULFONYL DERIVATIVES AND THEIR USE AS MUSCARINIC ACETYLCHOLINE RECEPTOR M5 INHIBITORS CHRM5, CHRM1, CHRM2 PKM 845/4885MAPT 2319/4885KEAP1 2063/4885
US-20110207772-A1 Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase DAGLB, DAGLA, MGLL PKM 3844/4885MAPT 4857/4885KEAP1 2888/4885
US-11560386-B2 Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto ADRB3, ADRB1, ADRB2 PKM 3124/4885MAPT 4632/4885KEAP1 1106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.