Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.53 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4234559 | 0.86 | P2RX7 (0.56) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL12181561 | 0.86 | P2RX7 (0.75) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL3329899 | 0.84 | NPC1 (0.70) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL16043466 | 0.83 | RAB9A (0.69) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL13847099 | 0.82 | POLB (0.60) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL14924434 | 0.82 | NPC1 (0.73) | NPC1RAB9AALDH1A1SLC6A12 | |
| SCHEMBL14094313 | 0.82 | HPGD (0.55) | NPC1RAB9ASLC6A12 | |
| SCHEMBL3455501 | 0.81 | RAB9A (0.72) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL8210765 | 0.81 | RAB9A (0.72) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL1286747 | 0.81 | BDKRB1 (0.50) | KMT2AMEN1ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287441-B1 | ACYLATED 4-AMINOPIPERIDINES AS INHIBITORS OF SERINE PALMITOYLTRANSFERASE | TAKEDA PHARMACEUTICALS CO (JP) | 2021-06-09 | — | — | EP | disclosed |
| EP-3287441-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |
| WO-2009112524-A1 | PYRIDOPYRIMIDINES AS PLK1 ( POLO-LIKE KINASE) INHIBITORS | 4SC AG (DE) | 2009-09-17 | — | — | WO | disclosed |