Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MMP13 | P45452 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | SPR | P35270 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373934 | 0.91 | HPGD (0.69) | HPGDLMNATSHRMAPK1MEN1 | |
| SCHEMBL4379760 | 0.84 | HPGD (0.64) | HPGDLMNATSHRMAPK1MEN1 | |
| SCHEMBL4375736 | 0.81 | ALDH1A1 (0.53) | HPGDLMNATSHRMAPK1MEN1 | |
| SCHEMBL31150982 | 0.80 | HPGD (0.75) | HPGDLMNATSHRMAPK1MEN1 | |
| SCHEMBL3583066 | 0.80 | MAPT (0.97) | HPGDLMNATSHRMEN1KMT2A | |
| SCHEMBL5190083 | 0.80 | MAPT (0.79) | HPGDLMNATSHRMAPK1MEN1 | |
| SCHEMBL4381941 | 0.80 | MAPT (0.74) | HPGDLMNATSHRMEN1KMT2A | |
| SCHEMBL3536006 | 0.79 | MAPT (1.00) | HPGDLMNATSHRMEN1KMT2A | |
| SCHEMBL22066283 | 0.78 | MMP13 (0.74) | HPGDLMNATSHRMEN1KMT2A | |
| SCHEMBL31150997 | 0.76 | HPGD (0.73) | HPGDLMNATSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686119-B1 | Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors | SMITHKLINE BEECHAM PLC (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-1686119-A1 | PYRIMIDINE-4-ONE DERIVATIVES AS LDL-PLA2 INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2006-08-02 | — | — | EP | disclosed |
| EP-1263740-B1 | PYRIMIDINE-4-ONE DERIVATIVE AS LDL-PLA2 INHIBITOR | SMITHKLINE BEECHAM PLC (GB) | 2006-07-19 | — | — | EP | disclosed |