Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 9/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374779 | 0.77 | ADORA2A (0.50) | ADORA1ADORA2AADORA2BADORA3FLT3 | |
| SCHEMBL4376249 | 0.77 | APP (0.46) | APPKMT2AMEN1HDAC3HDAC1 | |
| SCHEMBL1091872 | 0.75 | APP (0.50) | ADORA1ADORA2AADORA2BADORA3APP | |
| SCHEMBL7016043 | 0.73 | APP (0.58) | APPHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4376506 | 0.73 | MEN1 (0.44) | ADORA1ADORA2AADORA2BADORA3KMT2A | |
| SCHEMBL4374733 | 0.72 | ADORA2A (0.51) | ADORA1ADORA2AADORA2BADORA3APP | |
| SCHEMBL4376041 | 0.71 | APP (0.49) | ADORA1ADORA2AADORA2BADORA3APP | |
| SCHEMBL4376781 | 0.71 | APP (0.49) | ADORA1ADORA2AADORA2BADORA3APP | |
| SCHEMBL14869658 | 0.71 | HTR6 (0.62) | ADORA1ADORA2AADORA2BADORA3FLT3 | |
| SCHEMBL4377864 | 0.70 | APP (0.48) | ADORA1ADORA2AADORA2BAPPTMIGD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-B1 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-18 | — | — | EP | disclosed |