Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016043 | 0.85 | APP (0.58) | APPHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1090705 | 0.81 | HDAC1 (0.39) | KCNH3HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4377159 | 0.81 | APP (0.47) | APPKCNH3ABCB1MEN1ALDH1A1 | |
| SCHEMBL4376091 | 0.77 | ADORA1 (0.49) | APPMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL7011552 | 0.76 | LTA4H (0.46) | MEN1ALDH1A1KMT2AHDAC3HDAC1 | |
| SCHEMBL3447051 | 0.75 | CSF1R (0.47) | — | |
| SCHEMBL1317138 | 0.74 | DHFR (0.54) | — | |
| SCHEMBL7013050 | 0.73 | HTR7 (0.53) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1090916 | 0.73 | CHRNA7 (0.52) | MEN1ALDH1A1KMT2AHDAC3HDAC1 | |
| SCHEMBL4376349 | 0.72 | APP (0.52) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-B1 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-18 | — | — | EP | claimed |