Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.63 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.59 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 3/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479178 | 0.88 | AKT1 (0.64) | AKT1CAMKK2MAP3K5PDPK1CDK2 | |
| SCHEMBL13887692 | 0.83 | AKT1 (0.59) | AKT1CAMKK2MAP3K5PDPK1CDK2 | |
| SCHEMBL3349917 | 0.82 | AKT1 (0.44) | AKT1CAMKK2MAP3K5PDPK1CDK2 | |
| SCHEMBL22044129 | 0.82 | AKT1 (0.66) | AKT1CAMKK2MAP3K5PDPK1ROCK1 | |
| SCHEMBL4492515 | 0.81 | AKT1 (0.57) | AKT1CAMKK2MAP3K5PDPK1CDK2 | |
| SCHEMBL3355198 | 0.80 | AKT1 (0.53) | AKT1CAMKK2MAP3K5PDPK1CDK2 | |
| SCHEMBL30649183 | 0.80 | AKT1 (0.61) | AKT1CDK9CDK5ROCK1DAPK3 | |
| SCHEMBL10125059 | 0.80 | AKT1 (0.61) | AKT1CDK9CDK5ROCK1DAPK3 | |
| SCHEMBL13887780 | 0.80 | AKT1 (0.67) | AKT1CAMKK2MAP3K5PDPK1CDK2 | |
| SCHEMBL13888053 | 0.79 | MAP3K5 (0.56) | AKT1CAMKK2MAP3K5PDPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180370966-A1 | METHODS OF TREATMENT USING PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS, INC. | 2018-12-27 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| EP-2038272-B1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2013-09-04 | — | — | EP | disclosed |
| EP-2038272-A2 | PYRIDINONYL PDK1 INHIBITORS | Sunesis Pharmaceuticals, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008005457-A2 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180370966-A1 | METHODS OF TREATMENT USING PYRIDINONYL PDK1 INHIBITORS | PDK1, PDK2, PDK3 | AKT1 318/4885CAMKK2 327/4885MAP3K5 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.