Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190938 | 1.00 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL14190923 | 0.99 | KDM4E (0.58) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL4382800 | 0.99 | KDM4E (0.58) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL2829560 | 0.91 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL3773289 | 0.89 | KDM4E (0.51) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL3773292 | 0.89 | KDM4E (0.51) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL3769008 | 0.81 | RAB9A (0.49) | SMN1; SMN2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL3769019 | 0.81 | RAB9A (0.49) | SMN1; SMN2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL14218123 | 0.81 | TDP1 (0.64) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL13636365 | 0.81 | HPGD (0.47) | SMN1; SMN2KDM4EMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-7208497-B2 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2007-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | SMN1; SMN2 2684/4885KDM4E 1567/4885LMNA 4304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.