Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14190938 | 0.91 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL4377582 | 0.91 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL14190923 | 0.90 | KDM4E (0.58) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL4382800 | 0.90 | KDM4E (0.58) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL3773289 | 0.83 | KDM4E (0.51) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL3773292 | 0.83 | KDM4E (0.51) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL13090095 | 0.81 | HPGD (0.51) | SMN1; SMN2KDM4EMAPTALDH1A1KMT2A | |
| SCHEMBL8148362 | 0.81 | KDM4E (0.57) | SMN1; SMN2KDM4ELMNAGAAMAPT | |
| SCHEMBL2833140 | 0.81 | HPGD (0.50) | SMN1; SMN2KDM4EMAPTALDH1A1KMT2A | |
| SCHEMBL2831400 | 0.80 | ALDH1A1 (0.54) | SMN1; SMN2KDM4EGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |