Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.66 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.66 |
| ▸ | BCHE | P06276 | 14/20 | 0.58 |
| ▸ | ACHE | P22303 | 13/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991232 | 1.00 | HRH4 (0.66) | HRH4HRH3BCHEACHEPPARA | |
| SCHEMBL7987181 | 0.82 | GAA (0.55) | HRH4HRH3PPARAPPARG | |
| SCHEMBL7987202 | 0.78 | HRH2 (0.48) | PPARAPPARG | |
| SCHEMBL3000224 | 0.78 | BCHE (0.72) | BCHEACHEPPARAMAOAMAOB | |
| SCHEMBL3001883 | 0.78 | BCHE (0.72) | BCHEACHEPPARAMAOAMAOB | |
| SCHEMBL3000223 | 0.78 | BCHE (0.72) | BCHEACHEPPARAMAOAMAOB | |
| SCHEMBL3001884 | 0.78 | BCHE (0.72) | BCHEACHEPPARAMAOAMAOB | |
| SCHEMBL8934857 | 0.77 | HRH3 (0.39) | HRH4HRH3PPARAPPARG | |
| SCHEMBL25193715 | 0.77 | BCHE (0.70) | BCHEACHEPPARAMAOAMAOB | |
| SCHEMBL3001730 | 0.77 | BCHE (0.71) | BCHEACHEPPARAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | claimed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | claimed |
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| EP-0760811-A1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1997-03-12 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |