Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 14/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377879 | 0.97 | MEN1 (0.45) | MEN1KMT2AGSK3BNTRK1CYP2D6 | |
| SCHEMBL4385219 | 0.95 | MEN1 (0.43) | MEN1KMT2AGSK3BNTRK1CYP2D6 | |
| SCHEMBL4383616 | 0.91 | MEN1 (0.47) | MEN1KMT2ANTRK1ACKR3L3MBTL1 | |
| SCHEMBL3661764 | 0.90 | GSK3B (0.45) | MEN1KMT2AGSK3BCYP2D6CYP1A2 | |
| SCHEMBL4387202 | 0.89 | GSK3B (0.41) | MEN1KMT2AGSK3BCYP2D6CYP1A2 | |
| SCHEMBL2065359 | 0.89 | GSK3B (0.46) | MEN1KMT2AGSK3BCYP2D6CYP1A2 | |
| SCHEMBL4953302 | 0.89 | L3MBTL1 (0.53) | MEN1KMT2AGSK3BCYP3A4L3MBTL1 | |
| SCHEMBL3659720 | 0.89 | GSK3B (0.45) | MEN1KMT2AGSK3BCYP2D6CYP1A2 | |
| SCHEMBL4952879 | 0.88 | MEN1 (0.47) | MEN1KMT2ANTRK1CYP1A2CYP3A4 | |
| SCHEMBL3722894 | 0.87 | GSK3B (0.46) | MEN1KMT2AGSK3BCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |