Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393751 | 0.92 | KDM4E (0.46) | L3MBTL1GSK3BUGCGKDM4E | |
| SCHEMBL4387186 | 0.89 | L3MBTL1 (0.56) | L3MBTL1GAAMEN1KMT2AUGCG | |
| SCHEMBL4378646 | 0.89 | MEN1 (0.46) | L3MBTL1MEN1KMT2AGSK3BCYP3A4 | |
| SCHEMBL4377879 | 0.86 | MEN1 (0.45) | L3MBTL1MEN1KMT2AGSK3BCYP3A4 | |
| SCHEMBL4385219 | 0.84 | MEN1 (0.43) | L3MBTL1MEN1KMT2AGSK3BCYP3A4 | |
| SCHEMBL2065359 | 0.83 | GSK3B (0.46) | MEN1KMT2AGSK3B | |
| SCHEMBL4380168 | 0.83 | GSK3B (0.38) | GSK3B | |
| SCHEMBL4385660 | 0.82 | RAB9A (0.48) | L3MBTL1MEN1KMT2AGSK3BKDM4E | |
| SCHEMBL4388471 | 0.81 | KDM4E (0.47) | L3MBTL1GAAUGCGKDM4E | |
| SCHEMBL2066088 | 0.81 | GSK3B (0.40) | GSK3BCYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198287-B2 | Substituted heteroaryl pyridopyrimidone derivatives | SANOFI-AVENTIS (FR) | 2012-06-12 | — | — | US | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |