Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclofenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.77 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.77 |
| ▸ | TTR | P02766 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.77 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.77 |
| ▸ | FABP2 | P12104 | 1/20 | 0.77 |
| ▸ | RXRA | P19793 | 1/20 | 0.77 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.77 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.77 |
| ▸ | PDE4A | P27815 | 1/20 | 0.77 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.77 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.77 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.77 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenamic Acid SCHEMBL11543781 | 0.88 | PTGS2 (1.00) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL29379636 | 0.88 | PTGS2 (1.00) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL106 | 0.88 | PTGS2 (1.00) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL29373906 | 0.88 | PTGS2 (1.00) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL1320065 | 0.87 | PTGS2 (0.97) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL8927120 | 0.87 | PTGS2 (0.97) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL17200177 | 0.87 | PTGS2 (0.97) | PTGS2TTRMEN1MAPK1KMT2A | |
| SCHEMBL7346365 | 0.85 | PTGS2 (0.79) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL8193707 | 0.82 | PTGS2 (0.83) | PTGS2TTRMEN1MAPK1KMT2A | |
| Meclofenamic Acid SCHEMBL436190 | 0.82 | PTGS2 (0.83) | PTGS2TTRMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120063996-A1 | NOVEL NIMESULIDE COMPOSITIONS | ELAN PHARMA INTERNATIONAL LTD. | 2012-03-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120063996-A1 | NOVEL NIMESULIDE COMPOSITIONS | NIM1K, NIT2, NCL | PTGS2 2387/4885PTGS1 1780/4885TTR 2517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.