Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meclofenamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 7/20 | 0.83 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 4/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.83 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.83 |
| ▸ | TTR | P02766 | 3/20 | 0.83 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.83 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.83 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.83 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.83 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.83 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.83 |
| ▸ | FABP2 | P12104 | 1/20 | 0.83 |
| ▸ | RXRA | P19793 | 1/20 | 0.83 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.83 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.83 |
| ▸ | PDE4A | P27815 | 1/20 | 0.83 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meclofenamic Acid SCHEMBL436190 | 1.00 | PTGS2 (0.83) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL8465128 | 0.92 | PTGS2 (0.77) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL1538458 | 0.92 | PTGS2 (0.77) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL8531474 | 0.92 | PTGS2 (0.77) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL106 | 0.91 | PTGS2 (1.00) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL11543781 | 0.91 | PTGS2 (1.00) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL29373906 | 0.91 | PTGS2 (1.00) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL29379636 | 0.91 | PTGS2 (1.00) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL17200177 | 0.90 | PTGS2 (0.97) | PTGS2MEN1KMT2AAKR1C3TTR | |
| Meclofenamic Acid SCHEMBL8927120 | 0.90 | PTGS2 (0.97) | PTGS2MEN1KMT2AAKR1C3TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293583-A1 | PD1-SPECIFIC CHIMERIC ANTIGEN RECEPTOR AS AN IMMUNOTHERAPY | LONGWOOD UNIVERSITY | 2023-09-21 | — | — | US | disclosed |
| EP-1059930-A1 | COMPOSITIONS COMPRISING VALERIAN EXTRACTS, ISOVALERIC ACID OR DERIVATIVES THEREOF WITH A NSAID | NPS PHARMACEUTICALS, INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| EP-0977725-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 2000-02-09 | — | — | EP | disclosed |
| WO-1999044623-A1 | COMPOSITIONS COMPRISING VALERIAN EXTRACTS, ISOVALERIC ACID OR DERIVATIVES THEREOF WITH A NSAID | NPS PHARMACEUTICALS, INC. (US) | 1999-09-10 | — | — | WO | disclosed |
| WO-1998032718-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 1998-07-30 | — | — | WO | disclosed |