Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90B1 | P14625 | 3/20 | 0.45 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382774 | 0.86 | HSP90AA1 (0.56) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL10268436 | 0.77 | HRH3 (0.46) | HSP90B1TRAP1KMT2AKDM4EUSP2 | |
| SCHEMBL384701 | 0.74 | ABCB1 (0.44) | HSP90B1TRAP1NPC1RAB9AKDM4E | |
| SCHEMBL14223280 | 0.73 | KDM4E (0.55) | KDM4EUSP2CYP2D6TSHRLMNA | |
| SCHEMBL10256156 | 0.73 | BCHE (0.44) | HSP90B1TRAP1KDM4EUSP2EPHX2 | |
| SCHEMBL12853707 | 0.72 | CYP2D6 (0.59) | KDM4EUSP2CYP2D6TSHRLMNA | |
| SCHEMBL383211 | 0.71 | HSP90AA1 (0.58) | HSP90B1HSP90AA1HSP90AB1 | |
| SCHEMBL10269548 | 0.69 | ABHD6 (0.50) | MEN1NPC1RAB9AKMT2AUSP2 | |
| SCHEMBL383083 | 0.67 | HSP90AA1 (0.60) | HSP90B1TRAP1HSP90AA1HSP90AB1 | |
| SCHEMBL12015748 | 0.67 | ALDH1A1 (0.64) | MEN1NPC1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9730912-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2017-08-15 | — | — | US | disclosed |
| US-20090298818-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298818-A1 | PHARMACEUTICAL COMPOUNDS | H1-10, C1R, C1S | HSP90B1 3671/4885TRAP1 2584/4885MEN1 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.