Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2336896 | 0.84 | GPR119 (0.73) | GPR119HRH3 | |
| SCHEMBL13160653 | 0.83 | GPR119 (0.56) | GPR119CHRM2 | |
| SCHEMBL865044 | 0.83 | GPR119 (0.56) | GPR119CHRM2 | |
| SCHEMBL227404 | 0.83 | HRH3 (0.67) | GPR119HRH3MLNREPHX2 | |
| SCHEMBL225375 | 0.82 | GPR119 (0.91) | GPR119HRH3 | |
| SCHEMBL15051091 | 0.82 | GPR119 (0.58) | GPR119HRH3EPHX2 | |
| SCHEMBL18318099 | 0.81 | HRH3 (0.61) | GPR119HRH3MLNREPHX2 | |
| SCHEMBL3290157 | 0.81 | HRH3 (0.64) | GPR119HRH3MLNREPHX2 | |
| SCHEMBL4373488 | 0.80 | GPR119 (0.54) | GPR119HRH3CHRM2 | |
| SCHEMBL3340944 | 0.80 | GPR119 (0.85) | GPR119HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |