Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 16/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 16/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | CDC42 | P60953 | 1/20 | 0.58 |
| ▸ | RAC1 | P63000 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380166 | 1.00 | AKR1C3 (0.58) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL9116873 | 1.00 | AKR1C3 (0.58) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL9239300 | 0.88 | RXFP1 (0.47) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL7772358 | 0.88 | PTGS2 (0.45) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL9243634 | 0.88 | RXFP1 (0.44) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL10537008 | 0.88 | RXFP1 (0.47) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL9868774 | 0.85 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL9868769 | 0.85 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL9868760 | 0.85 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| Methoxymethane SCHEMBL10539889 | 0.84 | AKR1C3 (0.42) | AKR1C3AKR1C2PTGS2PTGS1CDC42 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532098-A1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | Nicox S.A. (FR) | 2005-05-25 | — | — | EP | claimed |
| WO-2004020384-A1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | NICOX S.A. (FR) | 2004-03-11 | — | — | WO | claimed |
| EP-0182279-B1 | PROCESS FOR THE OPTICAL RESOLUTION OF RACEMIC MIXTURES OF ALPHA-NAPHTYL-PROPIONIC ACIDS | ALFA WASSERMANN S.p.A. (IT) | 1990-02-28 | — | — | EP | claimed |
| EP-0182279-A1 | Process for the optical resolution of racemic mixtures of alpha-naphtyl-propionic acids | ALFA WASSERMANN S.p.A. (IT) | 1986-05-28 | — | — | EP | claimed |
| US-4423244-A | Process for the preparation of the d-2-(6-methoxy-2-naphthyl)-propionic acid | ALFA CHEMICALS ITALIANA S.P.A. (IT) | 1983-12-27 | — | — | US | claimed |
| CN-111978204-A | Preparation method of naproxen intermediate | 湖南大学 | 2020-11-24 | — | — | CN | disclosed |
| EP-1532098-B1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | NICOX SA (FR) | 2009-11-18 | — | — | EP | disclosed |
| US-7199258-B2 | Process for preparing nitrooxyderivatives of naproxen | NICOX S.A. (FR) | 2007-04-03 | — | — | US | disclosed |
| US-20060173005-A1 | Process for preparing nitrooxyderivative of naproxen | NICOX S.A. (FR) | 2006-08-03 | — | — | US | disclosed |
| EP-1532098-A1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | Nicox S.A. (FR) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004020384-A1 | PROCESS FOR PREPARING NITROOXYDERIVATIVES OF NAPROXEN | NICOX S.A. (FR) | 2004-03-11 | — | — | WO | disclosed |
| EP-0440930-B2 | Process for the debromination of 2-substituted-5-bromo-6-methoxynaphthalenes | ALFA CHEM ITAL (IT) | 2001-09-12 | — | — | EP | disclosed |
| EP-0035305-A2 | Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one | BLASCHIM S.p.A. (IT) | 1981-09-09 | — | — | EP | disclosed |
| EP-0034871-A2 | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals | BLASCHIM S.p.A. (IT) | 1981-09-02 | — | — | EP | disclosed |
| US-4045485-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC AND ANTIPRURITIC ACTIVITY | SYNTEX CORPORATION (US) | 1977-08-30 | — | — | US | disclosed |
| US-3994968-A | 2-(5'-Halo-6'-methoxynaphth-2'-yl)-acrylic acid | SYNTEX CORPORATION (PM) | 1976-11-30 | — | — | US | disclosed |
| US-3960957-A | 2-(6'-methoxynaphth-2'yl) propionaldoxime and 5'-halo derivatives thereof | SYNTEX CORPORATION (PM) | 1976-06-01 | — | — | US | disclosed |
| US-3960936-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIPYRETICS, SKIN DISORDERS | SYNTEX CORPORATION (PM) | 1976-06-01 | — | — | US | disclosed |
| US-3947472-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (PM) | 1976-03-30 | — | — | US | disclosed |
| US-3935273-A | ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, ANTIPRURITIC | SYNTEX CORPORATION (US) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173005-A1 | Process for preparing nitrooxyderivative of naproxen | CYP2A13, POR, CYP3A43 | AKR1C3 409/4885AKR1C2 970/4885PTGS2 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.