Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170586 | 0.98 | FAAH (0.53) | FAAHPLA2G2AMAPTTHRBMEN1 | |
| SCHEMBL2159594 | 0.98 | FAAH (0.53) | FAAHPLA2G2AMAPTTHRBPTGER3 | |
| SCHEMBL2168611 | 0.92 | PLA2G2A (0.56) | FAAHPLA2G2AMAPTMEN1KMT2A | |
| SCHEMBL3001541 | 0.91 | PTGER3 (0.45) | FAAHPLA2G2AMAPTPTGER3SMN1; SMN2 | |
| SCHEMBL3006040 | 0.91 | PLA2G2A (0.44) | FAAHPLA2G2AMAPTTHRBSMN1; SMN2 | |
| SCHEMBL2168630 | 0.89 | FAAH (0.64) | FAAHPLA2G2AMAPTMEN1KMT2A | |
| SCHEMBL3001888 | 0.88 | MAPT (0.46) | FAAHMAPTPTGER3SMN1; SMN2NPC1 | |
| SCHEMBL2169000 | 0.88 | FAAH (0.51) | FAAHPLA2G2AMAPTMEN1KMT2A | |
| SCHEMBL2159618 | 0.88 | FAAH (0.60) | FAAHPLA2G2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL2168110 | 0.88 | FAAH (0.65) | FAAHPLA2G2AMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |