Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.68 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.68 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | CASR | P41180 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655805 | 0.90 | TAAR1 (0.67) | TAAR1SIGMAR1SLC18A2SLC2A1CASR | |
| Methamphetamine SCHEMBL17008774 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL15094315 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL42178 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Levmetamfetamine SCHEMBL727412 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL4781849 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL13747483 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL20211416 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL42615 | 0.82 | SIGMAR1 (1.00) | TAAR1SIGMAR1SLC18A2 | |
| Methamphetamine SCHEMBL23035463 | 0.80 | SIGMAR1 (0.95) | TAAR1SIGMAR1SLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062511-B1 | IMMUNOASSAYS INVOLVING SURFACE ENHANCED RAMAN SCATTERING | UNIV STRATHCLYDE (GB) | 2009-11-25 | — | — | EP | disclosed |
| US-6750065-B1 | FOR USE IN DRUG OR EXPLOSIVE DETECTION | UNIVERSITY OF STRATHCLYDE (GB) | 2004-06-15 | — | — | US | disclosed |