Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13636009 | 0.91 | SMN1; SMN2 (0.59) | TDP1SMN1; SMN2ALDH1A1MAPTACHE | |
| SCHEMBL4377280 | 0.91 | SMN1; SMN2 (0.59) | TDP1SMN1; SMN2ALDH1A1MAPTACHE | |
| SCHEMBL4379174 | 0.81 | TDP1 (0.47) | TDP1SMN1; SMN2ALDH1A1MAPTACHE | |
| SCHEMBL14190948 | 0.81 | TDP1 (0.47) | TDP1SMN1; SMN2ALDH1A1MAPTACHE | |
| SCHEMBL14190945 | 0.80 | GPR183 (0.57) | TDP1ALDH1A1ACHEHPGDKDM4E | |
| SCHEMBL4381758 | 0.80 | GPR183 (0.57) | TDP1ALDH1A1ACHEHPGDKDM4E | |
| SCHEMBL4378985 | 0.80 | LMNA (0.59) | TDP1MAPTHPGDKDM4ELMNA | |
| SCHEMBL14190946 | 0.80 | LMNA (0.59) | TDP1MAPTHPGDKDM4ELMNA | |
| SCHEMBL17953098 | 0.80 | JUN (0.60) | JUNNFKB1ABCG2SMN1; SMN2ALDH1A1 | |
| SCHEMBL14218123 | 0.78 | TDP1 (0.64) | TDP1SMN1; SMN2ALDH1A1MAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1421071-B1 | SUBSTITUTED PIPERAZINE AND DIAZEPANE DERIVAIVES AS HISTAMINE H3 RECEPTOR MODULATORS | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-11-18 | — | — | EP | disclosed |