Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | CD69 | Q07108 | 2/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4642604 | 0.88 | CYP2C19 (0.65) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL4541506 | 0.85 | CYP2C19 (0.57) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL13757719 | 0.83 | CYP2C19 (0.74) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL13580642 | 0.80 | CYP2C19 (0.66) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL4241015 | 0.80 | PTGDR2 (0.61) | CYP2C19PTGDR2SMN1; SMN2PSEN1PSEN2 | |
| SCHEMBL13141657 | 0.79 | CYP2C19 (0.64) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL13624055 | 0.79 | CYP2C19 (0.68) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL17896571 | 0.78 | CYP2C19 (0.72) | CYP2C19PTGDR2SMN1; SMN2CD69ELANE | |
| SCHEMBL5302743 | 0.78 | PTGDR2 (0.63) | PTGDR2SMN1; SMN2ELANEPSEN1PSEN2 | |
| SCHEMBL7284155 | 0.78 | PTGDR2 (0.63) | CYP2C19PTGDR2SMN1; SMN2FFAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081222-A1 | SUBSTITUTED TRICYCLIC PYRIDINE OR PYRIMIDINE VANILLOID RECEPTOR LIGANDS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-07-02 | — | — | WO | disclosed |