Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 17/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017796 | 0.87 | OPRK1 (0.43) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4019776 | 0.82 | OPRM1 (0.46) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4021250 | 0.81 | OPRM1 (0.48) | OPRK1OPRM1OPRD1 | |
| SCHEMBL4023153 | 0.81 | OPRK1 (0.49) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4023573 | 0.81 | OPRK1 (0.44) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4023569 | 0.81 | OPRM1 (0.45) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4024054 | 0.80 | OPRM1 (0.44) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4021766 | 0.80 | OPRM1 (0.51) | OPRK1OPRM1OPRD1 | |
| SCHEMBL4019164 | 0.79 | OPRM1 (0.44) | OPRK1HRH3OPRM1OPRD1KCNH2 | |
| SCHEMBL4022809 | 0.79 | OPRK1 (0.44) | OPRK1OPRM1OPRD1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615893-B1 | 2-AZABICYCLO¬3.3.1 NONANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2009-11-18 | — | — | EP | disclosed |