Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381377 | 0.84 | HDAC8 (0.33) | HDAC8LMNACAPN1MAPTBACE1 | |
| SCHEMBL4390433 | 0.82 | CAPN1 (0.33) | HDAC8LMNACAPN1MAPTBACE1 | |
| SCHEMBL4388446 | 0.80 | EGFR (0.40) | HDAC8CAPN1GRM5 | |
| SCHEMBL4380826 | 0.76 | CAPN1 (0.38) | CAPN1MAPTBACE1ALDH1A1 | |
| SCHEMBL4378990 | 0.75 | HDAC3 (0.32) | HDAC8 | |
| SCHEMBL4383645 | 0.73 | CAPN1 (0.32) | HDAC8CAPN1BACE1GRM5 | |
| SCHEMBL4133119 | 0.71 | CYP3A4 (0.43) | HDAC8MAPTBACE1KDM4EGRM5 | |
| SCHEMBL28652556 | 0.71 | CYP3A4 (0.41) | HDAC8MAPTBACE1KDM4EALDH1A1 | |
| SCHEMBL2859836 | 0.70 | HSP90AB1 (0.35) | HDAC8LMNAMAPTBACE1KDM4E | |
| SCHEMBL22633087 | 0.70 | MAPT (0.39) | HDAC8LMNAMAPTBACE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7538241-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-26 | — | — | US | disclosed |
| US-20070155813-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| EP-1704856-A1 | HSP90 FAMILY PROTEIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-09-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155813-A1 | Hsp90 family protein inhibitors | HSP90AB1, HEATR1, HSP90AB2P | HDAC8 94/4885LMNA 4706/4885CAPN1 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.