Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12679220 | 0.86 | SCN9A (0.46) | KMT2AMEN1GRM5CYP3A4SCN9A | |
| SCHEMBL3508771 | 0.83 | MEN1 (0.50) | KMT2AMEN1GRM5EPHX2PPARG | |
| SCHEMBL4379672 | 0.81 | KMT2A (0.43) | KMT2AMEN1PLA2G1BATG4BHTT | |
| SCHEMBL16716171 | 0.79 | MEN1 (0.50) | KMT2AMEN1GRM5PPARGALDH1A1 | |
| SCHEMBL4336440 | 0.78 | CYP2D6 (0.41) | KMT2AMEN1PLA2G1BATG4BHTT | |
| SCHEMBL4583413 | 0.78 | KMT2A (0.50) | KMT2AMEN1RAB9ACYP3A4CYP2D6 | |
| SCHEMBL10254586 | 0.76 | TGM2 (0.49) | CACNA1FCACNA1DCACNA1SCACNA1CCYP3A4 | |
| SCHEMBL4374776 | 0.76 | CYP3A4 (0.48) | KMT2APLA2G1BATG4BRAB9ACYP3A4 | |
| SCHEMBL12681264 | 0.75 | MEN1 (0.45) | KMT2AMEN1GRM5ALDH1A1MAPT | |
| SCHEMBL5551458 | 0.75 | PLA2G1B (0.47) | KMT2AMEN1PLA2G1BATG4BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |