Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683030 | 0.85 | CTSS (0.52) | HTTALDH1A1LMNATSHRUBE2N | |
| SCHEMBL4379672 | 0.85 | KMT2A (0.43) | CYP2D6CYP2C9CYP2C19RAB9ACYP3A4 | |
| SCHEMBL12544607 | 0.84 | CA12 (0.39) | CYP2D6CYP2C9CYP2C19RAB9APIN1 | |
| SCHEMBL2636369 | 0.83 | PIN1 (0.43) | PIN1L3MBTL1ALDH1A1MEN1GAA | |
| SCHEMBL4374776 | 0.82 | CYP3A4 (0.48) | CYP2D6CYP2C9CYP2C19RAB9ACYP3A4 | |
| SCHEMBL4322435 | 0.82 | PIN1 (0.51) | CYP2D6CYP2C9CYP2C19RAB9ACYP3A4 | |
| SCHEMBL4583413 | 0.82 | KMT2A (0.50) | CYP2D6CYP2C9CYP2C19RAB9ACYP3A4 | |
| SCHEMBL4381682 | 0.78 | KMT2A (0.43) | CYP2D6CYP2C9CYP2C19RAB9ACYP3A4 | |
| SCHEMBL14870407 | 0.76 | ATM (0.47) | HTTALDH1A1HPGDMAPK1 | |
| SCHEMBL14870379 | 0.75 | TDP1 (0.47) | L3MBTL1ALDH1A1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158376-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158374-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158371-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLIKE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158373-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |